产品货号：
Z17323
中文名称：
GIT1抗体
英文名称：
Anti-GIT1 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GIT1 Antibody |
| 指标别名 | ARF GAP GIT1;CAT 1;CAT1;GIT1;GRK interacting protein 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | GIT1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Synthesized peptide derived from the C-terminal region of human GIT1.at AA rangle:530-610 |
| 计算分子量 | 84KD |
| 成分 | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| 纯化方式 | Immunogen affinity purified |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene.G-protein coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT-1 and GIT-2) are highly conserved,ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics.GIT proteins contain multiple interaction domains that allow interaction with small GTPases (including ARF,Rac and cdc42),kinases (such as PAK and MEK),the Rho family GEF PIX,and the focal adhesion protein paxillin.GIT-1 is localized to focal adhesions,cytoplasmic complexes and membrane protrusions,and regulates cell protrusion formation and cell migration.GIT-1 has also been implicated in neuronal functions including synapse formation and the pathology of Huntington disease.Huntington disease is a genetic neurodegenerative condition involving a mutation in the huntington gene.The huntington gene product (htt) is ubiquitinated and degraded in human Huntington disease brains.Htt interacts directly with GIT-1 causing enhanced htt proteolysis,indicating that GIT-1 distribution and function may contribute to Huntington disease pathology. |
| Uniprot ID | Q9Y2X7 |
| 基因名全称 | ARF GTPase-activating protein GIT1 |
| 推荐稀释比 | WB,1:500～1:2000 |
相关搜索：GIT1抗体，GIT1多抗，Anti-GIT1 Antibody